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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APP
All Species:
27.27
Human Site:
S441
Identified Species:
54.55
UniProt:
P05067
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05067
NP_958817.1
770
86943
S441
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Chimpanzee
Pan troglodytes
Q5IS80
770
86953
S441
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Rhesus Macaque
Macaca mulatta
XP_001104599
750
84778
S421
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Dog
Lupus familis
XP_856325
785
88788
A462
H
F
Q
A
M
V
K
A
L
E
K
E
A
A
S
Cat
Felis silvestris
Mouse
Mus musculus
P12023
770
86704
S441
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Rat
Rattus norvegicus
P08592
770
86686
S441
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989639
751
84687
S422
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Frog
Xenopus laevis
NP_001082098
749
84748
S420
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
Zebra Danio
Brachydanio rerio
NP_571639
738
83559
A424
H
F
Q
E
K
V
E
A
L
E
Q
E
S
A
S
Tiger Blowfish
Takifugu rubipres
O93279
737
82838
A421
H
F
Q
E
K
V
E
A
L
E
Q
E
A
A
G
Fruit Fly
Dros. melanogaster
P14599
887
98314
A469
R
F
Q
T
S
V
Q
A
L
E
E
E
G
N
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10651
686
79416
E377
K
A
Y
I
R
A
E
E
K
D
R
M
H
T
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
94.9
50.7
N.A.
96.6
96.8
N.A.
N.A.
91.8
84.8
69.7
67.2
26.2
N.A.
23.6
N.A.
Protein Similarity:
100
99.8
95.7
66.7
N.A.
97.5
97.9
N.A.
N.A.
94
90.9
80.5
78.9
41.5
N.A.
42.2
N.A.
P-Site Identity:
100
100
100
60
N.A.
100
100
N.A.
N.A.
100
100
80
86.6
40
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
N.A.
100
100
100
93.3
60
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
9
0
9
0
34
0
0
0
0
75
84
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% D
% Glu:
0
0
0
75
0
0
84
9
0
92
9
92
0
0
0
% E
% Phe:
0
92
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% G
% His:
84
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
75
0
9
0
9
0
9
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
92
0
0
0
0
0
9
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
59
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
92
0
0
0
9
0
0
0
75
0
0
0
0
% Q
% Arg:
9
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% R
% Ser:
0
0
0
0
9
0
0
59
0
0
0
0
9
0
17
% S
% Thr:
0
0
0
9
0
0
0
0
0
0
0
0
0
9
0
% T
% Val:
0
0
0
0
0
92
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _